Sam Rockwell Wolf (voice) Marc Maron Snake (voice) Awkwafina Tarantula (voice) Craig Robinson Shark (voice) Anthony Ramos Piranha (voice) Richard Ayoade Professor Marmalade (voice) Zazie Beetz Diane Foxington (voice) Alex Borstein Police Chief Misty Luggins (voice) Lilly Singh Tiffany Fluffit (voice) Barbara Goodson Old Lady (voice) Dina Morrone Museum Announcer / Diane's A.I. Assistant (voice) Kelly Cooney Cilella Prison Guard 1 / Gala Guest 1 (voice) Walt Dohrn Scientist / Gala Guest 3 (voice) David P. Smith Prison Guard 2 / Gala Guest 2 / Protestor (voice)