Chris Hemsworth Orion Pax / Optimus Prime (voice) Brian Tyree Henry D-16 / Megatron (voice) Scarlett Johansson Elita-1 (voice) Keegan-Michael Key B-127 (voice) Jon Hamm Sentinel Prime (voice) Steve Buscemi Starscream (voice) Laurence Fishburne Alpha Trion (voice) Vanessa Liguori Airachnid (voice) Jason Konopisos-Alvarez Shockwave / Guard 2 (voice) Evan Michael Lee Jazz (voice) James Remar Zeta Prime (voice) Isaac C. Singleton, Jr. Darkwing (voice) Steve Blum Announcer Bot / Guard 1 (voice) Jinny Chung Chromia / Arcee (voice) Josh Cooley Control Room Guys / PA System / Skywarp (voice)